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अमूर्त

VNTR Mutation in Monoamine Oxidase A in Depression and Anxiety: A Quantitative Survey

Kaan Yilancioglu*, Alihan Kocabas, Sevil Atasoy, Kubilay Gocucu, Inanc Pastirmaci

In this study, the relationship between Monoamine Oxidase A variable tandem repeat number genetic polymorphism and cognitive tests used for depression and anxiety were evaluated. The study aimed to determine whether Monoamine Oxidase A (MAOA) variable sequential repetition count could be an indicator that can be useful in diagnosing depression and anxiety. The beck depression inventory and beck anxiety inventory were applied to 102 individuals aged between 20-25 years. Oral epithelial cells and blood samples were collected for genetic analysis. DNA isolation of blood samples was performed, and the variable number of tandem repeat polymorphism was analyzed. The association between the beck depression and anxiety inventory results variable number of tandem repeat polymorphisms were evaluated statistically by the chi-square test or fisher’s exact test. While the results obtained proved a statistically significant relationship between Monoamine Oxidase A (MAOA) variable tandem repeat number genetic profiles in male subjects, a statistically significant impact could not be determined in the female group. The results used in the evaluation were obtained from the beck depression and anxiety inventories. The results obtained from the study provide promising outcomes about the utilization of genetic parameters and diagnostic criteria employed in clinical psychology.