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Two Cases of Spontaneous Hypoglycemia due to Insulin Autoantibody Syndrome – A Southern Indian Study

Anurag Yadav, Nanda Kumar L G, G Anmol Manaswini Yadav

IAS is a rare disease, characterized by hyperinsulinemic hypoglycaemia due to the development of autoantibodies against insulin, without prior treatment with insulin. Here we report two female cases of IAS, presenting in their 5th and 6th decades without prior exposure to any drugs that could induce antibody production. Both the patients were brought in unconscious state with a low blood sugar, ketonemia and demonstrated a high insulin levels in excess of 480 µIU/ml and demonstrable antibodies against insulin in the serum. Apart from genetic predisposition and the drugs that contain sulphydryl group, there could be other agents that induce this antibody production against insulin