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Studies on Ergosterol liquid membrane using Amphotericin B

Vandana Mishra

Amphotericin B is an antifungal polyene antibiotic obtained from a strain of Streptomyces nodosus. Some cancer tumors are composed of fungal tissue called ergosterol. Amphotericin B binds to ergosterol in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracellular components. To study the role of amphotericin B on ergosterol membrane, cellulose acetate matrix has been used as a support on which the liquid membrane of ergosterol has been formed. NaCl has been used as the electrolyte which is transported through the membrane. Membrane potential, perm selectivity and fixed charge density values have been used to examine the action of amphotericin B on ergosterol.