Bird P, Griffiths H and Littlejohn G
Methotrexate is the mainstay of treatment in rheumatoid arthritis (RA). Used for over 40 years as an anchor treatment in a number of rheumatic diseases, it remains a gold standard of therapy for RA. This review will provide a concise discussion of the efficacy and safety of methotrexate in rheumatic disease, with a focus on Rheumatoid Arthritis.