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एक्सेस जर्नल खोलें
- अभियांत्रिकी
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- औषधि विज्ञान
- कृषि और जलकृषि
- चिकित्सीय विज्ञान
- जीव रसायन
- जैव सूचना विज्ञान और सिस्टम जीवविज्ञान
- तंत्रिका विज्ञान और मनोविज्ञान
- नर्सिंग एवं स्वास्थ्य देखभाल
- नैदानिक विज्ञान
- पदार्थ विज्ञान
- पर्यावरण विज्ञान
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- भोजन एवं पोषण
- रसायन विज्ञान
- व्यवसाय प्रबंधन
- सामान्य विज्ञान
अमूर्त
GASTRIC CANCER RISK IN HELICOBACTER PYLORI INFECTED PATIENTS: A SYSTEMATIC OVERVIEW
Md. Zeyaullah & Vinod Kaul
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% (over 3 billion) of the world's population, mainly in the developing countries. Infection with H. pylori leads to a chronic inflammatory condition called severe chronic atrophic gastritis (SCAG) and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. Infection with H. pylori is the strongest known risk factor for gastric cancer. Gastric cancer ranks fourth in incidence and second in mortality among all cancers worldwide. People with SCAG have an increased risk of gastric adenomas in both the upper and lower parts of the stomach. Although H. pylori affects a large percentage of the population, only a small percentage of carriers develop this malignancy. Recent investigations have begun to identify the factors that lead to these complications. Such clinical diversities are caused by variations of H. pylori pathogenicity, host susceptibility, environmental factors, and interactions of these factors. The exact mechanisms underlying how H. pylori triggers or causes gastric cancer remain elusive.