दर्द प्रबंधन और चिकित्सा जर्नल

अमूर्त

Effetiveness of Duloxetine on Pain and Quality of Life in Chronic Back Pain in Patients who had Posterior Spinal Fixation (PSF)

Arezoo Samadi, Razieh Salehian, Danial Kiani and Atefeh Ghanbari Jolfaei

Background: Low back pain is a common disorder with high disability in physical and mental health. The prevalence
of low back pain is about 84% and in chronic cases (more than 3 months )is about 23%.For treatment pharmacological,
nonpharmacological and surgery are common. In this study we want to search the effectiveness of Duloxetine on pain and
quality of life in patients with chronic low back pain who had posterior spinal fixation.
Methods: In this randomized, placebo-controlled trial done in 6 months 50 patients who had CLBP and were candidated for
PSF surgery selected and divided in 2 groups (drug and placebo).
Results: Significant differences were evidenced among groups for Visual Analogue Scale (P= 0.005) and Verbal Analogue Scale
(p=0.003). Patients in the Duloxetine group have more visual and verbal pain score than the placebo group.
In quality of life, there was a significant difference between the two groups before the intervention. Data analysis showed that
there was a significant difference between pre and post intervention in Hamilton Anxiety Rating Scale only in duloxetine
group.
Also, in terms of quality of life, the subscales of "physical role", "emotional role", "physical pain" and "total score of quality of
life" in the duloxetine and placebo groups were significantly different between pre and post intervention.
Discussion: The results from this trial suggests that the use of duloxetine in patients who had spinal surgery can help to better
controlling of back pain, in the other hand can cause better psychological condition that affect quality of life.