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अमूर्त

Dynamic Resting State Functional Connectivity Differences between Ictal and the Pre or Postictal Phase of Migraine

Noboru Imai, Asami Moriya and Eiji Kitamura

Background: Migraine is a phasic disease, with ictal, preictal, and postictal phases. Aberrant static resting-state functional connectivity (rs-FC) has been demonstrated in migraine sufferers. However, there are few studies on dynamic rs-FC during migraine.

Methods: Migraineurs in the ictal (n=16), preictal (11), and postictal (10) phases underwent 3T MRI. We compared the static and dynamic rs-FC among subjects in the ictal, preictal, and postictal phases using region-of-interest to region-of-interest analyses of 91 cortical, 17 subcortical, and 30 infratentorial areas.

Results: Analysis of static rs-FC showed no significant differences among migraineurs in the ictal, preictal, and postictal phases. Analysis of dynamic rs-FC demonstrated that migraineurs in the ictal phase had significantly less connectivity between right thalamus and right insular cortex, between left PAG and right interior frontal gyrus, and six other region-of-interest pairs than migraineurs in the preictal phase as well as significantly less connectivity between the left thalamus and left cerebellum and six other region-of-interest pairs than migraineurs in the postictal phase.

Conclusions: In our study, dynamic rs-FC analysis revealed significantly different connectivity pairs between migraineurs in the ictal and pre- or postictal phases. Our study also revealed that the migraine brain dynamically changed rs-FC during the preictal, ictal, and postictal phases.