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D-ribose-L-cysteine Activated Autophagic Related Protein Pathway: A Possible Therapeutic Mechanism for Attenuating Testicular Maladaptive Responses

Mega O Oyovwi*, Ovuakporaye I Simon , Tesi P Edesiri, Ben-Azu Benneth, Emojevwe Victor,Nwangwan E Kingsley, Rotu A Rume, Falajiki Y Faith, Onome B Oghenetega, Ejime Agbonifo Chijiokwu.

Testicular maladaptive responses caused by toxicant induced Autophagic Related Protein-7(Atg7) and Mammalian Target of Rapamycin (mTOR) pathway deactivation is becoming a common fertility emergency that requires prompt therapeutic intervention in other to avoid potentially serious sequelae including loss of germ cell, deranged acrosome biogenesis to decreased male fertility, increased embryonic loss, and higher calf mortality. We therefore hypothesized that activation of a mTOR and Atg-7 may be a potential mechanism by which DRLC protects testicular cells and tissues from oxidative stress damage.