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Association of Trp53 arg72pro polymorphic variants with breast cancer - a case control study in south Indian population

*Suresh K, Venkatesan R, Chandirasekar R, Kumar BL, Sasikala K

The common single nucleotide polymorphism at Trp53 codon 72 is extensively analysed for its association with breast cancer, but conflicting evidences were obtained. We tested the hypothesis that the SNP at Trp53 codon 72 contributes to the development of breast cancer. Using the polymerase chain reaction-restriction fragment length polymorphism method, the genotype and allele distribution of the Trp53 codon 72 was determined among breast cancer patients (n=35) and healthy normal controls (n=37). Genotypic analysis revealed that the heterozygous (arg/pro) individuals were higher among breast cancer patients than in the controls. Overall, although there was no statistically significant difference in the allelic and genotypic distribution, higher number of arg allele was observed in breast cancer patients when compared to the controls suggesting that the arg allele may be associated with predisposing women to breast cancer.