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Alpha2-antiplasmin: A New Target for Fibrotic Diseases

Yosuke Kanno

Fibrotic diseases are characterized by excessive scarring due to excessive production, deposition, and contraction of the extracellular matrix (ECM). However, the detailed mechanism underlying the development of fibrosis was unclear. Recently, it has been reported that alpha2-antiplasmin (α2AP), which is serine protease inhibitors (serpins), is associated with the development of fibrosis. This review considers the physiological and pathological roles of α2AP in the development of fibrosis, and proposes that α2AP may be a new target for fibrotic disease.