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A Review of Cancer Persistent Cells: Lessons from Single-Cell Omics

Gongxin Peng & Yingsheng Zhang*

Cancer persistent cells are rare and commonly undetectable, which survive by entering drug-tolerant persistent states under cancer therapy. These cells, composed of genetic and non-genetic persistent cells, acquire drug resistance adapting to the drug treatment environment through various mechanisms, including genetic evolution, epigenetic modification, transcriptional regulation, proteomics interaction, cell metabolism remodeling, and cellcell communication. Aside from the robust fundamental understanding of cancer persistent cells we have gained in the past decade, rapid development of single-cell multi-omics in recent years provides new insights to understand the persistence state from the perspective of multi-omics.